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杩欓噷鏄爣棰樹竴h1鍗犱綅鏂囧瓧
鍙戝竷鏃堕棿锛
2021-01-25
鍏抽敭璇嶏細
浜哄伐鏅鸿兘,鏁板瓧,鐢熺墿浣
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鐢变簬 PAI 鏈川涓婃槸璺ㄥ绉戠爺绌讹紝鍥犳鐩稿叧鐮旂┒鎴愭灉鐨勫彈浼楄寖鍥存洿骞匡紝鏈夊彂琛ㄥ湪鏇撮珮褰卞搷鍔涙湡鍒婁笂鐨勬綔鍔涖€備絾鏄紝鐢变簬澶氬绉戠爺绌舵秹鍙婂埌骞挎硾鐨勪笓涓氱煡璇嗭紝椋庨櫓浼氭洿楂橈紝鎯呭喌涔熶細鏇村鏉傘€傚瀛︾涔嬮棿鍜屼箣涓殑鐮旂┒宸ヤ綔闇€瑕佹湁璧板嚭鑸掗€傚尯鐨勫媷姘旓紝鍘婚潰瀵硅嚜宸卞苟涓嶇啛鎮変笓涓氭湳璇拰浜洪檯缃戠粶锛岃€屼笖杩樺繀闇€鎸佺画涓嶆柇鐨勫涔犱互鍙婂潥鎸佷笉鎳堢殑鍐呭湪鍔ㄥ姏銆傛澶栵紝鑱屼笟鍙戝睍姝ラ涔熼渶瑕侀紦鍔卞拰濂栧姳璺ㄥ绉戠爺绌跺伐浣溿€備妇涓緥瀛愶紝鐜板浠婇泧浣ｆ暀鑱屼汉鍛樻椂锛屽線寰€浼氭牴鎹寖鍥寸嫮绐勭殑鐗瑰畾鐩爣棰嗗煙鎵ц锛岃€屼笉浼氫粠澶氬绉戣搴﹁€冭檻銆傞€氳繃闆囦剑鍦ㄤ覆鑱擖/span> PAI 鐩稿叧瀛︾鏂归潰鏈変笓闀跨殑鏁欒亴浜哄憳骞舵彁渚涘悎閫傜殑鏈烘瀯鏀寔锛岃兘涓鸿法瀛︾ PAI 鐮旂┒鎻愪緵鑷冲叧閲嶈鐨勬縺鍔便€傝繖浜涙楠よ兘鐩存帴鎺ㄨ繘 PAI 鐮旂┒锛屽悓鏃惰繕鑳介€氳繃楂樺奖鍝嶅姏鐨勬垚鏋滃彂甯冦€佷笓鍒╁拰鍚稿紩鐨勬姇璧勪负鏈烘瀯鐨勫０瑾夊甫鏉ヨ澶氬€嶇殑鍥炴姤銆侟/span>
姝ゅ锛屽垱閫犺鍙拰浼犳挱澶氬绉戠爺绌剁殑鍦烘墍涔熼潪甯搁噸瑕併€傚鏋滃皢 PAI 鐮旂┒鍒掑垎鍒颁紶缁熺殑绉戠爺绀惧尯锛屾瘮濡傛潗鏂欑瀛︺€佸姏瀛︺€佹湁鏈哄寲瀛︾瓑锛屽垯鍙兘鏀剁獎涓€涓瀛﹂棶棰樼殑灞曠ず绌洪棿锛屽嵆鍙兘灞曠ず璇ョ壒瀹氱ぞ鍖鸿兘澶熺悊瑙ｇ殑閮ㄥ垎銆傝繖绉嶆柟寮忕己涔忔暣浣撹閲庯紝涔熶笉鑳界悊瑙ｈ闂鐨勬暣浣撳鏉傛€с€傚挨鍏舵槸鏈哄櫒浜哄鍜屼汉宸ユ櫤鑳介鍩燂紝闇€瑕佷竴绉嶆洿骞挎硾鐨勫瀛︾璁よ瘉妯″紡锛屽苟涓旇浣垮叾娉ㄩ噸瀛︾鍜屼笓涓氱煡璇嗕箣闂寸殑澶嶆潅浜や簰鍏崇郴銆備綔鑰呮彁鍑哄垱寤哄拰鏀寔浠?/span> PAI 鐨勫鏉傚瀛︾鎸戞垬涓虹洰鏍囩殑鐮旂┒鑰呯ぞ鍖恒€佷細璁拰鏈熷垔銆備粬浠篃寤鸿閫氳繃涓嶅悓瀛︾鍏卞悓缁勭粐璁剧珛绔炰簤鎬х殑濂栧閲戙€佸鍔卞拰濂栭噾锛屼互鏀寔绀惧尯灞傞潰鐨勫弬涓庛€侟/span>
涓堻/span> 鎬荤粨
鍦ㄨ繖绡囨枃绔犱腑锛屼綔鑰呮彁鍑洪€氳繃鍒涢€燑/span> PAI 鏉ョ爺鍙戠敤浜庡叡鐢熷紡浜虹被-鏈哄櫒浜虹敓鎬佺郴缁熺殑鏈哄櫒浜猴紝杩涜€屽紩棰嗘湭鏉ユ暟鍗佸勾鐨勬満鍣ㄤ汉鐮旂┒銆傜洰鍓嶈€岃█锛岀ぞ鍖鸿繕缂轰箯鍒涢€燑/span>PAI 鎵€闇€鐨勫瀛︾鎶€鑳斤紝鑰屽ぇ澶氭暟鏈烘瀯浠嶈繕娌℃湁涓鸿繖涓€鎸戞垬鎬х殑澶氬绉戠爺绌舵柟鍚戝缓绔嬪熀纭€璁炬柦銆備綔鑰呮彁鍑轰簡鍑犵偣鎺ㄨ繘PAI 鎶€鑳芥暀鑲茬殑閫斿緞锛氶€氳繃鍒涘缓婵€鍔辨€х殑鏈烘瀯鍜岀ぞ鍖虹幆澧冩潵鍚屾椂鍩硅瀛︾敓鐨勫瀛︾鎶€鑳藉拰鏀寔瀵煎笀鐨勬椿鍔ㄣ€傞渶瑕佽鏄庯紝鏈枃鐨勭洰鏍囨槸寮鸿皟鏁欒偛涓嬩竴浠Ⅻ/span> PAI 鐮旂┒鑰呯殑閲嶈鎬э紝鑰屼笉鏄粰鍑鸿缁嗙‘鍒囩殑鏈€缁堣鍔ㄧ翰棰嗐€傚笇鏈涚瀛﹀拰鐮旂┒绀惧尯鑳藉氨杩欎竴涓婚灞曞紑鏇村箍娉涚殑璁ㄨ锛屼簰鐩镐氦娴佷笉鍚岀殑鎰忚鍜屾柟娉曘€侟/span>
鍙傝€冮摼鎺ワ細
https://www.nature.com/articles/s42256-020-00258-y
https://www.nature.com/articles/s42256-020-00258-y.epdf?no_publisher_access=1&r3_referer=nature
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